Molecular Dynamics Study of Cancer-Associated H2BE76K Mutation Effects on Nucleosome

Valentina Migliorati's research investigates the H2BE76K oncohistone mutation's impact on nucleosome stability and dynamics using Molecular Dynamics simulations. The 8.2 MB PDF document compares wild-type and mutant forms, detailing local hydrogen bond loss and long-range conformational repercussions. The dataset was last updated on May 13, 2026, and is shared under a CC-BY-4.0 license.

Use Cases

• Compare nucleosome stability between wild-type and mutant forms based on the described MD simulation results.
• Analyze the propagation of local structural perturbations to long-range DNA contacts based on the described mechanistic link.
• Study the relationship between histone tail flexibility and DNA interaction dynamics based on the described shift from single to multiple interactions.

Strengths

• The dataset provides a detailed mechanistic explanation of mutation effects, as described in the summary.
• The data is openly shared under a CC-BY-4.0 license, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a single 8.2 MB PDF file, which is a small scale for computational analysis.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Valentina Migliorati

Collection Method

Molecular Dynamics simulations

Freshness

Last updated 2026-05-13 05:50:55; freshness should be verified.