Systematic Review of Circadian Interventions in Pediatric Intensive Care

A 2025 systematic review and meta-analysis synthesized data from 41 studies involving 2,548 patients in neonatal and pediatric intensive care units. It compares the effectiveness of single versus combined circadian interventions on physiological outcomes and sleep. The analysis includes pooled effect sizes for heart rate, respiratory rate, oxygen saturation, and sleep duration.

Use Cases

• Analyze pooled effect sizes (SMD) for heart rate and respiratory rate to quantify the impact of circadian interventions.
• Compare outcomes from single interventions like cycled lighting against multicomponent bundles using subgroup analysis results.
• Assess the certainty of evidence graded using the GRADE approach across the 41 included studies.
• Examine the risk of bias assessments conducted with Cochrane RoB 2 and ROBINS-I tools for methodological quality.

Strengths

• Synthesizes data from 41 primary studies with a total sample of 2,548 patients.
• Reports specific pooled effect sizes (SMD) with confidence intervals for key physiological outcomes like oxygen saturation (+1.33).
• Follows PRISMA 2020 guidelines and includes a systematic review registration (OSF.IO/8SPZM).

Limitations

• The certainty of evidence is graded as low due to inability to blind interventions and statistical heterogeneity.
• Limited primary research in pediatric settings, requiring cautious interpretation of results for that population.
• The dataset is a 206.5 KB PDF document containing summarized meta-analysis results, not raw patient-level data.

Provenance

Source

Constanza C. Corrotea-Maltez via figshare.

Collection Method

Systematic review and meta-analysis following PRISMA 2020 guidelines, searching five major databases (PubMed, ScienceDirect, CINAHL, WoS, Scopus) and others.

Time Range

Literature search covered from database inception to 2025.

Freshness

Last updated March 2026, with literature search conducted up to 2025.