Effects of Sugar-Lipid Ratio Diets on Type 2 Diabetes in a Mouse Model

A research document details a study on the effects of varying dietary sugar-to-fat ratios on the progression of type 2 diabetes mellitus. The study involved 40 C57BL/6 mice across a control and three high-energy diet groups, with longitudinal monitoring of body weight and blood glucose, followed by serum, proteomic, and metabolomic analyses. The document, authored by Wenjie Sun and last updated in April 2026, is shared under a CC-BY-4.0 license.

Use Cases

• Analyzing the dose-dependent relationship between dietary fat content and metabolic disease onset based on longitudinal body weight and blood glucose data.
• Investigating molecular pathways of lipid metabolism dysregulation based on integrated proteomic and metabolomic profiling of liver tissue.
• Studying the effects of macronutrient composition on organ histopathology and insulin resistance based on described analyses of liver, pancreas, and adipose tissue.
• Validating specific molecular targets like AMPK, PGC-1α, and PPARs in the context of diet-induced mitochondrial dysfunction.

Strengths

• The study design includes a controlled experiment with 40 mice across four distinct diet groups.
• Analytical depth is indicated by the use of integrated proteomics and untargeted metabolomics, identifying 4,276 hepatic metabolites.
• Key molecular findings, such as the suppression of mitochondrial markers and dysregulation of lipid regulators, are validated with specific assays.

Limitations

• The dataset is a 725.2 KB DOCX file, which is a text document; the underlying raw experimental data is not directly provided.
• Column-level documentation for any potential supplementary data is absent; field semantics must be inferred after download.
• Row count for any tabular data within the document is unknown, which may limit suitability assessment.

Provenance

Source

Wenjie Sun via figshare

Collection Method

Controlled laboratory experiment on C57BL/6 mice with subsequent multi-omics analysis.

Time Range

The study period is not specified.

Freshness

Last updated 2026-04-23 04:16:30; freshness should be verified.

Geography

The geographic origin of the study is not specified.