Network Meta-Analysis of Diabetic Foot Ulcer Non-Pharmacological Interventions

A network meta-analysis of 24 randomized controlled trials evaluating 15 non-pharmacological interventions for diabetic foot ulcer healing. The study, authored by Jiaxing Zheng and published in 2026, compares interventions like Negative Pressure Wound Therapy and Gas Therapy on outcomes including 12-week healing rate and healing time.

Use Cases

• Compare the relative effectiveness of 15 intervention types, such as Negative Pressure Wound Therapy + Standard Care, on the 12-week healing rate outcome.
• Analyze SUCRA rankings from the network meta-analysis to identify the best-performing interventions for shortening healing time.
• Evaluate evidence certainty by examining the risk of bias assessments conducted using the Cochrane RoB 2.0 tool across the 24 included trials.

Strengths

• Analysis synthesizes evidence from 24 randomized controlled trials.
• Compares 15 distinct non-pharmacological intervention types for diabetic foot ulcers.
• Systematic review protocol was pre-registered (PROSPERO CRD420251122143).
• Includes quality assessment using the Cochrane risk of bias tool (RoB 2.0).

Limitations

• Evidence is based on a limited number of small-sample studies, as noted in the conclusion.
• Findings have wide confidence intervals, indicating limited certainty.
• The dataset is a 163.3 KB DOCX file containing a manuscript, not structured tabular data for direct computational analysis.

Provenance

Source

figshare

Collection Method

Systematic review and network meta-analysis of RCTs from 8 databases including PubMed, Embase, and Cochrane.

Time Range

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Freshness

Last updated March 2026.

Geography

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