Data Sheet 1_Efficacy and safety of ALA/MLA photodynamic therapy for superficial and nodul

Meiyu Jiang's systematic review and meta-analysis, uploaded on 2026-04-14, aggregates evidence from 55 studies involving 2123 patients and 2995 lesions. The 22.3 MB document compares complete response, recurrence, and cosmetic outcomes for superficial and nodular basal cell carcinoma treated with ALA-PDT or MAL-PDT. It follows PRISMA 2020 guidelines, analyzing data from PubMed, Embase, Cochrane Library, and Web of Science up to December 31, 2025.

Use Cases

• Compare complete response rates for superficial vs. nodular BCC subtypes based on the pooled rates reported in the meta-analysis.
• Analyze heterogeneity sources in PDT outcomes based on the identified factors of study design, light dose, and number of treatment sessions.
• Evaluate the safety profile of PDT based on the reported pooled adverse event incidence for sBCC and the descriptions of local reactions for nBCC.
• Assess the performance of novel PDT formulations like BF-200 ALA and AFL-MAL based on the reported promising complete response rates.

Strengths

• Aggregates data from 55 eligible studies, providing a substantial evidence base.
• Reports specific pooled outcome rates with confidence intervals, such as a 0.88 complete response rate for sBCC and 0.75 for nBCC.
• Includes detailed subgroup analyses identifying key factors contributing to heterogeneity.

Limitations

• The primary data format is a DOCX document; column-level documentation and sample data are unavailable for direct analysis.
• Row count for any underlying data is unknown, which may limit suitability assessment for quantitative modeling.
• The description is detailed but the actual structured dataset (if any) behind the review is not directly accessible.

Provenance

Source

Author: Meiyu Jiang. Platform: figshare.

Collection Method

Systematic review and meta-analysis conducted per PRISMA 2020 guidelines, searching PubMed, Embase, Cochrane Library, and Web of Science.

Time Range

Literature search covers studies up to December 31, -2025.

Freshness

Last updated 2026-04-14 05:36:35; includes literature search up to December 31, 2025.

Geography

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