Meta-Analysis of Gabapentinoid Combination Therapy for Neuropathic Pain, 21 Trials
by Dandan Li·Updated 2mo ago
2.3 MB1files
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Description
A systematic review and meta-analysis comparing the efficacy and safety of gabapentinoid combination therapy versus monotherapy for neuropathic pain. The analysis includes 21 clinical trials comprising 2204 patients, with data abstracted from PubMed, Web of Science, Embase, and Cochrane Library up to November 4, 2025. The dataset was authored by Dandan Li and published on figshare in April 2026.
Use Cases
Compare pain score reduction between combination and monotherapy based on the primary outcome measure.
Analyze safety profiles and adverse event rates for specific drug combinations, such as opioid-gabapentinoid pairs.
Investigate treatment efficacy for specific neuropathic pain conditions like painful diabetic neuropathy (PDN) and postherpetic neuralgia (PHN) based on subgroup analyses.
Assess secondary outcomes like sleep interference scores and Patient Global Impression of Change (PGIC) response rates.
Strengths
Analysis is based on 21 clinical trials comprising 2204 patients, providing a substantial evidence base.
Systematic review methodology follows PRISMA guidelines and uses Cochrane risk-of-bias tools, suggesting a structured approach.
Includes primary and secondary outcome measures (pain scores, sleep interference, PGIC, adverse events) for a multi-faceted comparison.
Limitations
Column-level documentation is absent; field semantics must be inferred after download.
Row count is unknown, which may limit suitability assessment for certain analytical tasks.
The data is presented in a PDF format, which may require extraction for computational analysis.
Provenance
Source
Systematic search of PubMed, Web of Science, Embase, and Cochrane Library.
Collection Method
Data abstraction and quality assessment conducted per PRISMA and Cochrane guidelines.
Time Range
Studies from database inception to November 4, 2025.
Freshness
Last updated 2026-04-13 04:35:16; freshness should be verified.
Geography
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Data is provided as a 2.3 MB PDF file; text extraction or manual review is required for analysis.