Efficacy and Safety of Lung-Protective Ventilation in Neurosurgery: A Meta-Analysis

Yan Liu's meta-analysis, published on figshare in 2026, synthesizes results from seven randomized controlled trials involving 523 craniotomy patients. The study compares lung-protective ventilation to conventional ventilation, analyzing outcomes like postoperative pulmonary complications, intracranial pressure, and lung compliance. The dataset is a 15.8 KB document containing the full systematic review and meta-analysis.

Use Cases

• Training or validating models for predicting postoperative pulmonary complications based on ventilation strategy.
• Conducting secondary meta-analyses on the efficacy of lung-protective ventilation in surgical settings.
• Informing clinical guideline development for perioperative care in neurosurgery based on aggregated trial evidence.

Strengths

• Includes data from seven randomized controlled trials, a standard for clinical evidence.
• Reports specific statistical results, such as an odds ratio of 0.30 for reducing overall postoperative pulmonary complications.
• Covers multiple secondary outcomes including intracranial pressure, lung compliance, and oxygenation.

Limitations

• The dataset is a 15.8 KB document; the underlying patient-level trial data is not provided.
• Row count and column-level documentation for any underlying data are unknown.
• Conclusions on intracranial pressure are based on surrogate measures, as noted in the description.

Provenance

Source

Systematic review and meta-analysis by author Yan Liu, sourced from figshare.

Collection Method

Aggregated from randomized controlled trials identified in PubMed, Embase, the Cochrane Library, and WANFANG databases.

Time Range

Trials published between 2000 and 2025.

Freshness

Last updated 2026-04-23 05:35:56.