Data Sheet 1_Efficacy of drug regimens containing omadacycline in a murine model of Mycoba

A preclinical study evaluates the efficacy of omadacycline alone and in combination with other antibiotics against Mycobacterium avium complex lung infection in mice. The dataset likely contains results from 9 treatment regimens assessed over 4 months based on bacterial load reduction in lung and spleen tissues. The data was authored by Jean-Philippe Lanoix and last updated on 2026-05-29.

Use Cases

• Compare the efficacy of different antibiotic combinations based on the described 9 treatment regimens.
• Analyze the time-course of bacterial load reduction based on measurements taken over a 4-month period.
• Evaluate omadacycline's performance relative to a standard-of-care regimen based on the described comparison with rifampin.
• Identify the most potent drug combination based on the reported >5 log10 reduction in bacterial burden.

Strengths

• The description provides specific efficacy metrics, including a >5 log10 reduction for the most potent combination.
• The study design is clearly outlined, evaluating 9 distinct treatment regimens over a defined 4-month period.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small in size (800.7 KB), indicating a limited scope of data.

Provenance

Source

figshare

Collection Method

Results from a preclinical murine aerosol infection model study.

Freshness

Last updated 2026-05-29 05:52:59; freshness should be verified.