Data Sheet 1_EGFR-targeted photoimmunotherapy and its association with the immune microenv

A clinical dataset from a retrospective study of 25 patients with locoregional recurrent head and neck squamous cell carcinoma (HNSCC) treated with EGFR-targeted photoimmunotherapy (RM-1929). The data includes treatment response, overall survival, safety profiles, and multiplex immunohistochemistry analysis of the tumor immune microenvironment from 14 pretreatment and 6 paired pre/post-treatment samples. The dataset was authored by Koichi Yoshizawa and last updated on April 10, 2026.

Use Cases

• Predicting treatment response based on intratumoral CD39+CD8+ T cell density mentioned in the description
• Analyzing longitudinal immune microenvironment remodeling after photoimmunotherapy based on paired pre/post-treatment samples
• Correlating clinical outcomes with multiplex immunohistochemistry markers like PD-L1+ immune cells
• Studying the safety profile and efficacy of a novel EGFR-targeted photoimmunotherapy modality

Strengths

• Includes multiplex immunohistochemistry data for 14 markers from 14 patients
• Contains longitudinal data with 6 paired pre- and post-treatment samples
• Clinical outcomes are detailed, including an overall response rate of 77.5% and median overall survival of 401 days
• Published under a CC-BY-4.0 license for open reuse

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Dataset is small in scale (807.2 KB), representing a limited patient cohort of 25 individuals

Provenance

Source

figshare

Collection Method

Retrospective clinical evaluation and multiplex immunohistochemistry performed on patient tumor samples.

Time Range

Not specified in the provided metadata.

Freshness

Last updated 2026-04-10 05:58:02; freshness should be verified

Geography

Not specified in the provided metadata.