Postoperative Gut Microbiota and IL-1β Analysis from Thoracoscopy Study

A clinical and laboratory study investigates the relationship between postoperative IL-1β, gut microbiota oxygen phenotypes, and patient outcomes. The research uses 16S rRNA gene sequencing and Bugbase phenotype analysis on a cohort of thoracoscopy patients and a mouse model. It identifies correlations between IL-1β levels, anaerobe abundance, and postoperative complication risks.

Use Cases

• Analyze the correlation between postoperative IL-1β levels and gut microbiota oxygen phenotypes like obligate anaerobe and facultative anaerobe abundance.
• Investigate the association of facultative anaerobe abundance with clinical outcomes such as postoperative complication risk and hospital stay length.
• Model the IL-1β–colonic epithelial oxygen metabolism–colonic oxygen environment–gut microbiota regulatory axis using data from mouse surgery/anesthesia stress experiments.
• Use Bugbase phenotype analysis results to study the postoperative shift from obligate anaerobes to aerobes/facultative anaerobes.

Strengths

• Integrates clinical cohort data from thoracoscopy patients with controlled laboratory mouse model experiments.
• Employs 16S rRNA gene sequencing and Bugbase phenotype analysis for gut microbiome characterization.
• Dataset is openly shared under a CC BY 4.0 license, facilitating reuse.

Limitations

• The dataset is very small at 19.1 KB, contained within a single DOCX file, limiting analytical scope.
• Specific sample sizes for the clinical cohort and mouse model are not provided in the input.
• The data is presented as a research document, not a structured, queryable table, requiring significant extraction effort.

Provenance

Source

figshare, authored by Wanyu Wang.

Collection Method

Clinical cohort study with 16S rRNA sequencing and Bugbase analysis, complemented by a controlled mouse model experiment.

Time Range

Perioperative period for the clinical cohort; specific dates not provided.

Freshness

Last updated on 2026-03-23.

Geography

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