Genomic and Clinical Data on Multidrug-Resistant Streptococcus pneumoniae Pericarditis

Lin Liu's figshare submission provides genomic and clinical insights from a case of Streptococcus pneumoniae pericarditis, comparing two bacterial isolates from blood and pericardial effusion. The analysis includes whole-genome sequencing, antimicrobial susceptibility testing, and phenotypic assays against a background of 1429 global serotype 14 genomes. It documents specific mutations like CiaH_W192L and FabT_E21A linked to altered bacterial growth and virulence.

Use Cases

• Analyze the 36 SNP differences between the hz23B and hz23P isolates to study within-host bacterial evolution during pericarditis.
• Model protein structures for the unique CiaH_W192L and FabT_E21A mutations to investigate their impact on kinase function and DNA-binding.
• Compare antimicrobial susceptibility test (AST) profiles of the ST876 clone against other serotype 14 genomes to assess multidrug resistance patterns.
• Use the phylogenetic analysis of 1429 global serotype 14 genomes to trace the dominance and spread of the ST876 clone.

Strengths

• Provides a direct genomic comparison of two related bacterial isolates (hz23B and hz23P) from a single patient, highlighting 36 specific SNP differences.
• Contextualizes findings against a large-scale phylogenetic analysis of 1429 global serotype 14 Streptococcus pneumoniae genomes.
• Includes detailed phenotypic data on bacterial growth under anaerobic stress, adherence, and invasion on epithelial cell lines linked to specific mutations.

Limitations

• The core clinical and genomic data is limited to a single patient case, restricting statistical power and generalizability.
• Primary data is embedded within a narrative research document (DOCX), requiring extraction for computational analysis.
• Sample data and structured columns are unavailable, complicating direct reuse for tabular analysis or machine learning.

Provenance

Source

Lin Liu via figshare.

Collection Method

Clinical isolates from a purulent pericarditis patient underwent whole-genome sequencing, mutation detection, antimicrobial susceptibility testing, and phenotypic assays.

Freshness

Last updated March 2026.

Geography

Primary case from China, with comparative analysis including global serotype 14 genomes.