Murine Sepsis Model Data on PD-L1 Role in Lung Injury and Mortality

Experimental data from a study using Cre-lox mouse models to investigate the role of programmed cell death receptor-ligand 1 (PD-L1) in shock/sepsis-induced lung injury. The dataset includes survival rates, lung vascular permeability measurements, and cytokine, chemokine, and angiopoietin levels from blood, bronchoalveolar lavage fluid, and lung tissue. Authored by Elizabeth W. Tindal and shared on figshare under a CC-BY-4.0 license, last updated in June 2026.

Use Cases

• Analyzing the differential impact of endothelial cell versus neutrophil PD-L1 deficiency on mortality based on 14-day survival data.
• Investigating lung vascular permeability changes based on Evan’s Blue dye exclusion assay results.
• Correlating cytokine/chemokine levels (e.g., MCP-1, MIP-2, IL-6, Angiopoietin 2) with specific cell-type deficiencies and organ injury.
• Comparing immune marker profiles across different biological samples (blood, BALF, lung tissue) from the described experimental groups.

Strengths

• Data is derived from controlled Cre-lox mouse models allowing cell-type-specific (endothelial vs. neutrophil) analysis of PD-L1.
• Includes multiple biological readouts: survival, vascular permeability, and a panel of cytokine/chemokine/angiopoietin assays.
• Shared under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• The dataset is described in a single 243.4 KB PDF file; underlying raw data tables are not directly accessible.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The study uses a specific murine model (C57BL/6) and experimental protocol (Hem/CLP), which may limit generalizability.

Provenance

Source

Elizabeth W. Tindal via figshare.

Collection Method

Data generated from laboratory experiments using Cre-lox mouse models subjected to hemorrhagic shock and cecal ligation and puncture (CLP).

Freshness

Last updated 2026-06-02 04:28:48.