Rat Organ Protein Levels After Endurance Training

Lukasz Galganski published a dataset on figshare in 2026 detailing protein expression changes in rats following endurance training. The data includes measurements of interleukin-6 (IL-6), transmembrane tumor necrosis factor-alpha (tmTNF-α), soluble TNF-α (sTNF-α), hypoxia-inducible factor 1 subunit alpha (HIF-1α), and lysine demethylase 6A (KDM6A) across five organs. The dataset is 896.7 KB and is available under a CC-BY-4.0 license.

Use Cases

• Modeling organ-specific inflammatory responses based on IL-6 and tmTNF-α protein level changes.
• Analyzing the relationship between exercise and hypoxia signaling based on HIF-1α and KDM6A protein expression.
• Comparing central nervous system versus peripheral organ adaptations to endurance training based on brain-specific protein level decreases.
• Investigating differential roles of TNF-α isoforms in exercise adaptations based on tmTNF-α and sTNF-α measurements.

Strengths

• Data covers protein expression in five distinct vital organs: lungs, liver, skeletal muscle, heart, and brain.
• The study design includes a controlled 8-week endurance training protocol for male Wistar rats.
• Dataset focuses on specific proteins (IL-6, tmTNF-α, sTNF-α, HIF-1α, KDM6A) relevant to inflammation and hypoxia pathways.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small in scale at 896.7 KB, indicating limited scope.

Provenance

Source

Lukasz Galganski

Collection Method

Male Wistar rats performed treadmill running (30–60 min/day, 5 days/week) for 8 weeks. Protein expression was assessed via methods described in the accompanying PDF.

Freshness

Last updated 2026-05-14 04:30:15; freshness should be verified.