Mouse Model Data for Tuberculosis Vaccine Efficacy via Heterologous Prime-Pull Strategy

A 2.2 MB PDF research article authored by Marcellus Korompis, last updated April 20, 2026. The document details a study testing heterologous mRNA-ChAdOx1 vaccination strategies in C57BL/6 mice to enhance protection against Mycobacterium tuberculosis. Results include quantification of T-cell responses, antibody levels, and lung/spleen bacterial load (CFU) reductions.

Use Cases

• Analyzing the efficacy of heterologous versus homologous vaccine regimens based on CFU reduction data mentioned in the description.
• Studying the induction of lung-resident memory T cells (TRM) based on intravascular and tetramer staining results.
• Comparing immune response profiles (CD4+, CD8+, IgG) between systemic and mucosal vaccine administration routes.
• Evaluating prime-pull strategies as a booster for BCG vaccination based on the reported log10 CFU reductions.

Strengths

• Specific quantitative results are reported, including a 0.8 log10 CFU reduction in lungs and spleen.
• Detailed methodological description of vaccination regimens, cellular assays, and challenge models.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is a single PDF document; underlying tabular or raw experimental data is not directly accessible.
• Column-level documentation is absent; field semantics must be inferred from the article text.
• Row count is unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

figshare

Collection Method

Experimental study in a mouse model, as described in the research article.

Time Range

Study period not specified in metadata.

Freshness

Last updated 2026-04-20 05:22:38

Geography

Laboratory study; geographic scope not specified.