Oral Mucosal Candida and T Cell Dysfunction in Aging and HIV

A 402.7 KB PDF research data sheet from figshare, authored by S. Jayaraman and last updated on March 19, 2026. It investigates the association between fungal dysbiosis, specifically Candida enrichment, and CD4+FOXP3+ regulatory T cell accrual and dysfunction in the oral mucosa of individuals over 60 years old, with comparisons to younger individuals and stratification by HIV status.

Use Cases

• Correlating Candida abundance with mucosal Treg levels based on described positive relationship.
• Analyzing age-associated fungal dysbiosis patterns based on the comparison of taxa between older and younger individuals.
• Investigating the role of IL-6 in Treg dysfunction based on described in vitro mechanistic insights.
• Comparing oral mycobiome composition between HIV-positive and healthy aging groups based on the stratified analysis.

Strengths

• Data is associated with a specific mechanistic hypothesis linking Candida to Treg dysfunction via IL-6.
• Analysis is stratified by both age (>60) and HIV status, allowing for comparative insights.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is a 402.7 KB PDF, which is a small, likely summary document rather than raw data.
• Column-level documentation and sample data are unavailable, limiting assessment of data structure.
• The geographic and specific demographic scope of the study population is not detailed.

Provenance

Source

figshare, author S. Jayaraman.

Collection Method

Likely derived from a research study involving oral mucosal sampling, fungal sequencing, and flow cytometry of gingival tissues.

Freshness

Last updated 2026-03-19 05:17:38