Neonatal HIE Feeding Timing and Outcomes from a Single-Center Retrospective Study

94 neonates with moderate to severe hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia were studied from March 2024 to March 2025. The data, shared by Weihong Yue on figshare, compares early versus delayed enteral feeding groups on outcomes like gastrointestinal adverse events and hospitalization costs. No significant difference in gastrointestinal adverse events was found between groups, but early feeding was associated with shorter parenteral nutrition duration and reduced costs.

Use Cases

• Analyze associations between feeding timing and clinical outcomes like gastrointestinal adverse events based on the described cohort groups.
• Study the impact of disease severity on outcomes such as necrotizing enterocolitis incidence based on the severe HIE subgroup analysis.
• Investigate potential confounding by indication using variables like invasive ventilation and hemodynamic support rates mentioned in the results.
• Model healthcare resource utilization by examining outcomes like parenteral nutrition duration and hospitalization costs associated with feeding strategy.

Strengths

• Includes data on 94 neonates with detailed group comparisons (EEF n=48, DEF n=46).
• Reports specific outcome metrics, including gastrointestinal adverse event rates (22.9% vs. 21.7%) and adjusted odds ratios (OR=0.75).
• Provides temporal context with a defined study period from March 2024 to March 2025.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Data is from a single-center study, which may limit generalizability.
• The dataset is small at 108.4 KB, indicating limited scope.

Provenance

Source

Children's Hospital of Chongqing Medical University

Collection Method

Single-center retrospective cohort study.

Time Range

March 2024 to March 2025

Freshness

Last updated 2026-04-23 05:34:33; freshness should be verified.

Geography

Chongqing, China