Data Sheet 1_Entorhinal cortex atrophy mediates the association of plasma p-tau181, GFAP,

A study of 89 Parkinson's disease patients and 40 healthy controls by Qiangqiang Wan, last updated in May 2026. It includes plasma biomarker measurements (p-tau181, GFAP, NfL), high-resolution structural MRI scans, and cognitive assessment scores from the Montreal Cognitive Assessment (MoCA). The data supports analysis of biomarker associations with cognitive impairment and brain atrophy.

Use Cases

• Training models to predict cognitive scores based on plasma biomarker levels mentioned in the description.
• Analyzing the mediating role of entorhinal cortex atrophy on biomarker-cognition relationships as described.
• Investigating stage-specific biomarker effects, such as NfL's moderated mediation in mild cognitive impairment.
• Developing integrative risk stratification models combining plasma biomarkers with MRI-derived atrophy measures.

Strengths

• Includes data from 129 participants (89 PD patients, 40 controls) with detailed cognitive and biomarker profiling.
• Biomarkers were measured using single-molecule array technology, a sensitive method.
• All participants underwent both high-resolution structural MRI and standardized cognitive assessment (MoCA).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 16.0 KB, suggesting limited raw data or a summary document.

Provenance

Source

figshare, author Qiangqiang Wan.

Collection Method

Data collected from a clinical study enrolling patients and controls, with biomarker assays, MRI, and cognitive testing.

Time Range

null

Freshness

Last updated 2026-05-08 05:55:53; freshness should be verified.

Geography

null