Data Sheet 1_Environmental exposures and atopic dermatitis: an umbrella review of systemat

An umbrella review synthesizing evidence from 20 systematic reviews and meta-analyses on environmental risk factors for atopic dermatitis. The document, authored by Sijia Chen and shared under a CC-BY-4.0 license, was last updated in May 2026. It categorizes exposures such as antibiotics, smoking, air pollution, PFAS, and heavy metals, analyzing their associations with AD risk across children, adults, and mixed-age populations.

Use Cases

• Identify robust environmental risk factors for atopic dermatitis based on synthesized meta-analytic evidence.
• Compare age-specific susceptibility to exposures like antibiotics and air pollution as described in the review.
• Guide future research priorities by highlighting exposures with limited or inconsistent evidence, such as PFAS and pet exposure.
• Inform public health interventions and environmental management strategies for AD prevention.

Strengths

• Synthesizes evidence from 20 systematic reviews and meta-analyses, providing a consolidated view.
• Explicitly categorizes exposures into distinct groups (microbe- and immune-related, pollution, lifestyle/residential).
• Assesses methodological quality using the AMSTAR 2 tool and prioritizes fully adjusted estimates.
• Focuses on age-stratified findings, distinguishing evidence for children, adults, and mixed-age populations.

Limitations

• The dataset is a 76.2 KB DOCX document, indicating a limited textual summary rather than raw or structured data.
• Row count and column-level documentation are absent; the underlying data tables from the included reviews are not provided.
• Freshness should be verified as the last update date is in the future (2026-05-15).

Provenance

Source

figshare

Collection Method

Systematic search of PubMed, Embase, and Web of Science up to March 2026 for systematic reviews and meta-analyses.

Time Range

Reviews included up to March 2026.

Freshness

Last updated 2026-05-15 05:41:05