E. coli and M. morganii Stress Response Data with Genomic and Phenotypic Measurements

An exploratory study of clinical and environmental bacterial strains from Ghanaian tertiary hospitals exposed to extreme pH, temperature, osmotic, and antibiotic stress. Growth kinetics were monitored via OD600 and CFU, and persister-like cell formation was assessed using time-kill assays at 2 × MIC antibiotic conditions. Comparative whole genome sequencing captured genomic changes in stress-recovered isolates relative to parental strains.

Use Cases

• Modeling bacterial growth kinetics under environmental stress based on OD600 and CFU data
• Analyzing genomic adaptations to stress based on comparative whole genome sequencing results
• Investigating links between environmental stress and antibiotic tolerance based on persister-like cell formation assays
• Studying strain-specific phenotypic differences in response to heat and antibiotic stress

Strengths

• Data includes comparative whole genome sequencing results for stress-recovered isolates
• Phenotypic measurements cover multiple stress types: pH (3, 9, 10), temperature (~4°C, ~45°C), and hyperosmolarity (1.71M NaCl)
• File size is 768.1 KB, indicating a focused and manageable dataset

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data may reflect geographic bias inherent to the Ghanaian hospital source

Provenance

Source

Tosin Yetunde Senbadejo via figshare

Collection Method

Laboratory experiments on bacterial strains with growth monitoring, time-kill assays, and whole genome sequencing

Time Range

null

Freshness

Last updated 2026-03 17 13:32:47; freshness should be verified

Geography

Strains sourced from Ghanaian tertiary hospitals