Epimedium Effects on Alzheimer's Disease: KAT2B and Neuroinflammation Data

Experimental data from a study investigating Epimedium's therapeutic effects on Alzheimer's disease in a rat model. The dataset likely contains results from cognitive tests, histopathology, ELISA, and qRT-PCR analyses measuring targets like KAT2B, NF-κB, IL-1β, and TNF-α. The dataset was authored by Jie Gao and last updated on April 20, 2026.

Use Cases

• Analyzing the relationship between KAT2B expression and cognitive deficits based on the described qRT-PCR and Morris water maze results.
• Investigating the effect of Epimedium on neuroinflammatory markers based on the described IL-1β and TNF-α level data.
• Correlating histopathological changes in hippocampal neurons with behavioral outcomes based on the described H&E staining and cognitive assessments.
• Studying the interaction between predicted herb targets and Alzheimer's disease-associated genes based on the described bioinformatics screening of 172 key targets.

Strengths

• Data is derived from a multi-method study combining bioinformatics prediction, in vivo modeling, and molecular assays.
• The dataset is licensed under CC-BY-4.0, permitting open sharing and reuse.
• The study design includes control groups and measures multiple endpoints (cognitive, histopathological, inflammatory).

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small at 13.2 KB, indicating limited scope and likely a summary of results rather than raw experimental data.
• The description metadata is limited; actual data structure and quality require manual inspection.

Provenance

Source

figshare, authored by Jie Gao.

Collection Method

Data likely generated from laboratory experiments on a rat Alzheimer's disease model, combined with bioinformatics screening from TCMSP, PubChem, and gene databases.

Time Range

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Freshness

Last updated 2026-04-20 04:12:09; freshness should be verified.

Geography

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