Mouse Behavioral and Protein Data for Esketamine Depression Study

14.8 MB of data from a study investigating the antidepressant effects of esketamine on mice subjected to chronic social defeat stress. The dataset, created by Hang Yu and uploaded in April 2026, includes behavioral test results and protein expression measurements from the prefrontal cortex.

Use Cases

• Analyze the correlation between social interaction ratio and NRG1 protein expression levels in susceptible mice.
• Model changes in forced swimming immobility time at 30 minutes and 24 hours post-esketamine injection.
• Compare sucrose preference ratio and immunofluorescence data across control, susceptible, and resilient mouse groups.
• Investigate the relationship between GAD67 and ErbB4 expression levels following pharmacological intervention.

Strengths

• Data is derived from a controlled experiment with defined control, susceptible, and resilient subject groups.
• Includes temporal measurements at baseline, 30 minutes, and 24 hours post-treatment for key behavioral indicators.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and sharing.

Limitations

• The 14.8 MB size suggests a limited number of observations, potentially restricting statistical power for complex analyses.
• Sample data and column names are unavailable, complicating initial data exploration and understanding of structure.
• Data is specific to a mouse model (CSDS), limiting direct translatability to human depression studies.

Provenance

Source

Hang Yu, via the figshare repository.

Collection Method

Data collected from a laboratory experiment using a Chronic Social Defeat Stress (CSDS) mouse model, behavioral tests, and protein/immunofluorescence analysis.

Time Range

Covers experimental periods before and after esketamine injection (30-minute and 24-hour timepoints).

Freshness

Last updated April 2026, indicating recent data availability.