E. coli Urinary Tract Infection Model in Göttingen Minipigs with Strain Recovery Data

Joyce Lübbers published a dataset on 2026-05-18 describing the establishment of a novel intraurethral urinary tract infection model using uropathogenic E. coli strain UTI89 in Göttingen minipigs. The dataset includes results from a 14-day infection study, with bacterial enumeration, agglutination tests, and whole genome sequencing of recovered strains. The 195.8 KB document reports that 75% of animals were infected with the challenge strain, while 25% had a different E. coli strain recovered.

Use Cases

• Benchmarking strain recovery and verification protocols based on the described agglutination and whole genome sequencing methods.
• Designing preclinical UTI studies based on the intraurethral challenge model using Foley balloon catheters.
• Analyzing model limitations based on the reported finding of non-challenge strain recovery in 25% of animals.

Strengths

• Dataset includes specific quantitative results, such as a 75% infection rate with the challenge strain.
• The methodology for establishing the 14-day infection model is described in detail.
• Data is associated with a specific, characterized E. coli strain (UTI89).

Limitations

• The dataset is a 195.8 KB DOCX file, which is a very small text document, not a structured data table.
• Row count and column-level documentation are absent; data structure must be inferred from the narrative.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Joyce Lübbers via figshare

Collection Method

Experimental study involving intraurethral challenge of minipigs with UPEC strain UTI89, followed by bacterial enumeration, agglutination testing, and whole genome sequencing of recovered bacteria.

Freshness

Last updated 2026-05-18 05:45:01; freshness should be verified.