Systematic Review of Animal Models for Skin Wound Healing, 2015-2025

A systematic review of 129 studies published between January 1, 2015, and December 31, 2025, synthesizing animal models for skin wound healing. The review, authored by Ying Zhang and shared on figshare, categorizes and evaluates acute, chronic, and pathological scarring models in mice, rats, and rabbits.

Use Cases

• Selecting appropriate animal models for wound healing experiments based on the review's categorization of acute, chronic, and scarring models.
• Designing studies to address translational challenges based on identified model limitations, such as contraction-dominant healing in rodents.
• Incorporating sex-specific considerations in study design based on the review's identification of a pervasive male bias and hormone effects.
• Developing composite chronic wound models based on the review's identification of gaps in diabetic models lacking macrovascular complications.

Strengths

• Based on a systematic review of 129 studies, following PRISMA guidelines.
• Covers a defined time range of studies from 2015 to 2025.
• Assesses methodological quality using SYRCLE's risk of bias tool.

Limitations

• The dataset is a 94.7 KB PDF document; the underlying data tables are not provided.
• Row count and column-level documentation for any extracted data are unknown.
• The review's conclusions are based on the included literature, which may have inherent publication biases.

Provenance

Source

Ying Zhang via figshare.

Collection Method

Systematic literature review of PubMed, Web of Science, and Scopus.

Time Range

Studies published between 2015 and 2025.

Freshness

Last updated 2026-04-16 04:20:29.

Geography

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