Cytokine and Protein Expression Data from a Buccal Patch Study in Experimental Models

A 5.2 MB document uploaded by Rekha Rani Kokkanti to figshare on 2026-05-27. The data sheet describes a study evaluating a multi-component mucoadhesive buccal patch, measuring cytokine and protein expression in in vitro and in vivo models of oral inflammation and fibrosis. The dataset includes results from qPCR gene expression analysis of IL-6, TNF-α, MMP-2, IL-2, and TGF-β, as well as protein expression of COX-2 and CK17.

Use Cases

• Analyze cytokine expression patterns (IL-6, TNF-α, TGF-β) based on treatment with a multi-drug buccal patch described in the study.
• Investigate correlations between inflammatory markers (COX-2, MMP-2) and fibrotic progression based on the described in vivo model results.
• Study enzymatic activity of bromelain in a drug formulation based on the described collagen degradation assay results.
• Model treatment effects on tissue architecture and functional outcomes (mouth opening) based on the described histological and functional assessments.

Strengths

• Dataset is licensed under CC-BY-4.0, permitting broad reuse with attribution.
• Description provides specific details on measured biomarkers (IL-6, TNF-α, MMP-2, IL-2, TGF-β, COX-2, CK17) and experimental models (LPS-induced in vitro, CCl4-induced in vivo).
• File size is 5.2 MB, indicating a document likely containing detailed textual and potentially tabular results.

Limitations

• Row count is unknown, which may limit suitability assessment for quantitative analysis.
• Column-level documentation is absent; field semantics must be inferred after download.
• The primary data format is DOCX, which may require parsing to extract structured data for analysis.

Provenance

Source

figshare

Collection Method

Experimental study using qPCR gene expression analysis, protein expression examination, collagen degradation assays, and histological analysis.

Freshness

Last updated 2026-05-27 20:01:31; freshness should be verified.