Aggressive Posterior ROP Registry Data from Germany

21 infants diagnosed with aggressive posterior retinopathy of prematurity (AP-ROP) were compared to 329 control infants treated for other ROP forms in a German registry study. The dataset includes neonatal parameters, treatment details, and functional outcomes for infants born between 2011 and 2020. Analysis confirmed risk factors like lower gestational age and birth weight for AP-ROP development.

Use Cases

• Analyze the association between gestational age and birth weight with AP-ROP diagnosis compared to other ROP forms.
• Compare treatment patterns, such as intravitreal anti-VEGF therapy versus laser photocoagulation, across AP-ROP and control groups.
• Model the risk of requiring retreatment based on ROP type and treatment method using the registry's clinical outcomes.
• Investigate functional outcomes like central fixation and strabismus prevalence in AP-ROP eyes after approximately 12 months follow-up.

Strengths

• Contains data on 350 total infants (21 AP-ROP cases, 329 controls) from a national clinical registry.
• Includes specific, statistically significant clinical findings like gestational age (24.3 vs. 25.4 weeks) and birth weight (595 vs. 697g) differences.
• Reports detailed treatment outcomes, including retreatment rates (39% vs. 15%) and follow-up functional assessments.

Limitations

• Small sample size of 21 AP-ROP cases limits statistical power for multivariate analysis.
• Geographic focus is solely on Germany, which may limit generalizability to other populations.
• Specific column names and data structure are not provided in the input, complicating immediate analysis.

Provenance

Source

German Retina.net ROP registry.

Collection Method

Observational registry data analysis comparing infants with AP-ROP to a control group.

Time Range

Infants born between 2011 and 2020.

Freshness

Data covers births from 2011 to 2020, with the record last updated in March 2026.

Geography

Germany.