Tissue-Engineered Blood Vessel Data for In Vitro Cardiovascular Testing

Tissue-engineered blood vessels (TEBVs) fabricated from smooth muscle and endothelial cells provide a three-dimensional in vitro model for studying intimal hyperplasia. The dataset, authored by Diana M. Rojas-González and last updated in May 2026, describes experiments where TEBVs were subjected to arterial flow for 21 days and interventions like balloon angioplasty and stent implantation. Results include measurements of vessel wall thickness, lumen diameter, endothelial coverage, and cytokine levels.

Use Cases

• Validate in vitro models of intimal hyperplasia based on the described TEBV fabrication and bioreactor protocol.
• Compare vascular response to interventions like plain old balloon angioplasty (POBA) and drug-eluting stents (DES) based on the reported optical coherence tomography and cytokine data.
• Study endothelial and smooth muscle cell crosstalk in a three-dimensional environment based on the model's described cell seeding and co-culture conditions.

Strengths

• Model dimensions and wall thickness are described as resembling human coronary arteries, enhancing physiological relevance.
• Experimental timeline is specified, including a 21-day bioreactor culture and intervention at day 7.
• Quantitative results are reported for specific cytokines (IL-6, IL-8, MCP-1) and cellular markers (Ki67, αSMA).

Limitations

• The dataset is a 678 KB DOCX file; the underlying structured data (e.g., raw measurements, column definitions) is not directly accessible.
• Row count and specific data formats for numerical results are unknown, requiring extraction from the document.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Diana M. Rojas-González.

Collection Method

Data originates from laboratory experiments fabricating tissue-engineered blood vessels and testing them under flow conditions.

Freshness

Last updated 2026-05-18 05:52:57; freshness should be verified.