CROSSBRAIN: Ex Vivo Imaging of Wireless Implantable Microdevices in Brain Tissue

A 2026 preliminary ex vivo study from the CROSSBRAIN EU project, authored by Teresa Giannattasio. It presents an integrated imaging workflow for visualizing 100 × 100 × 50 μm³ silicon dummy microdevices within brain tissue, combining 2D histology with 3D X-ray Phase Contrast Tomography and micro-CT. The dataset, shared as a 779.8 KB PDF on figshare, establishes a methodological foundation for future in vivo tracking of implantable neuromodulation devices.

Use Cases

• Benchmarking 3D imaging techniques for visualizing micro-scale implants based on the described synchrotron X-ray Phase Contrast Tomography (XPCT) and micro-CT workflow.
• Developing image analysis pipelines for precise device localization within complex tissue architecture, as referenced in the description.
• Planning targeted histological sectioning guided by non-destructive 3D imaging, a strategy mentioned in the study.
• Feasibility studies for tracking foreign body response to implanted devices under physiologically relevant conditions, a stated goal of the project.

Strengths

• Describes a technically robust, integrated imaging workflow combining multiple high-resolution techniques.
• Focuses on a specific, challenging problem: visualizing 100 × 100 × 50 μm³ devices incompatible with standard MRI.
• Provides a clear methodological foundation for future in vivo studies within the CROSSBRAIN project.

Limitations

• The dataset is a 779.8 KB PDF document; the underlying raw image data is not directly provided.
• Row count and column-level documentation for any potential supplementary data are unknown.
• The study is explicitly preliminary and ex vivo; results are not from functional devices in living organisms.

Provenance

Source

Teresa Giannattasio, part of the CROSSBRAIN EU project.

Collection Method

Ex vivo study using silicon dummy microdevices and an integrated workflow of histology, synchrotron X-ray Phase Contrast Tomography (XPCT), and micro-Computed Tomography (micro-CT).

Freshness

Last updated 2026-06-02 05:40:17.