Exhausted CD4+T Cells and CCL4-Driven Macrophage Accumulation in Bovine Leukosis

A research article analyzing immune remodeling in enzootic bovine leukosis (EBL), a B-cell lymphoma caused by bovine leukemia virus. The study investigates chemokine production, macrophage phenotypes, and monocyte recruitment within tumor-affected lymph nodes. The 2.3 MB PDF document was authored by Hayato Nakamura and last updated on May 4, 2026.

Use Cases

• Study chemokine-driven immune cell recruitment based on CCL4 expression analysis described in the paper
• Analyze macrophage phenotypic shifts based on the reported changes in CD163, PD-L1, and MHC molecule expression
• Investigate immunosuppressive tumor microenvironments based on the described accumulation of altered macrophages in bovine leukosis

Strengths

• The dataset is a detailed research article with a specific focus on immune mechanisms in a veterinary cancer model
• File size is 2.3 MB, indicating a contained and likely focused document
• License is CC-BY-4.0, permitting broad reuse and distribution

Limitations

• The primary data format is a PDF, which may require text extraction for computational analysis
• Row count and column-level documentation are absent; data structure must be inferred from the narrative
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Likely contains experimental data from immunological assays and analysis described in the research article.

Time Range

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Freshness

Last updated 2026-05-04 04:24:21; freshness should be verified

Geography

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