Data Sheet 1_Exploring In situ neuroprotective mechanisms of nicotine in an MPTP-Induced P

A 1.1 MB document by Lutao Xu, last updated May 2026, describes a spatial metabolomics study of Parkinson's disease. The research used AFADESI-MSI to map metabolic changes across whole brains from MPTP-induced PD rats and to define the in situ metabolic effects of nicotine treatment.

Use Cases

• Study region-dependent metabolic disruption in Parkinson's disease based on spatial metabolomics data.
• Investigate nicotine's neuroprotective effects on neurotransmitter balance based on metabolite restoration patterns.
• Analyze recovery of membrane lipid homeostasis based on glycerophospholipid metabolism pathway data.
• Examine mitochondrial stress markers based on AMP and glutathione level changes.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• Description provides detailed methodological context for AFADESI-MSI spatial metabolomics.

Limitations

• The primary data file is a 1.1 MB DOCX document; the underlying raw data files are not specified.
• Column-level documentation is absent; field semantics must be inferred from the description.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Airflow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI) applied to MPTP-induced Parkinson's disease rat models.

Freshness

Last updated 2026-05-01 05:24:50; freshness should be verified.