Neutrophil Extracellular Trap Markers for Major Depressive Disorder

Two independent clinical cohorts (Cohort 1: n=83; Cohort 2: n=60) and a mouse model were used to study neutrophil extracellular traps (NETs) in major depressive disorder. Plasma levels of three NET markers—MPO-DNA, NE-DNA, and citH3—were measured in patients and healthy participants. The data was authored by Yachen Shi and last updated on 2026-05-12.

Use Cases

• Diagnostic model development based on plasma NET marker levels.
• Predicting treatment response based on changes in Hamilton Depression Rating Scale scores.
• Investigating the link between neuroinflammation and depressive symptoms based on correlations with inflammatory indices.
• Validating animal models of depression by comparing hippocampal NET levels in CUMS mice.

Strengths

• Data is validated across two independent clinical cohorts totaling 143 human participants.
• Includes results from a chronic unpredictable mild stress (CUMS) mouse model for biological validation.
• Examines three specific NET markers (MPO-DNA, NE-DNA, citH3) and their clinical correlations.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (771.1 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Clinical study measuring plasma NET markers in MDD patients and healthy controls, supplemented by a CUMS mouse model.

Freshness

Last updated 2026-05-12 04:18:59; freshness should be verified.