Data Sheet 1_Exploring the molecular mechanism of Coptis-cinnamon in combating gastric can

16 active components and 499 targets of the Coptis-Cinnamon (HL-RG) pair were identified, intersecting with 55 common targets from 3,194 gastric cancer-related genes. The research, authored by Zhao-zhao Wang and uploaded to figshare in May 2026, includes molecular docking, enrichment analyses, and in vitro experiments on AGS and HGC-27 cells. Results indicate the herbal pair inhibits gastric cancer cell proliferation, migration, and invasion via the MAPK/ERK pathway.

Use Cases

• Identifying potential drug targets for gastric cancer based on the 55 common intersection targets between HL-RG and disease genes.
• Validating molecular interactions via in silico docking based on core components like berberine and hub genes like PDGFRB.
• Analyzing pathway enrichment for drug mechanism discovery based on KEGG and GO analyses highlighting the MAPK pathway.
• Designing in vitro experiments for cancer therapeutics based on described methods including CCK-8, flow cytometry, and Western blot.

Strengths

• Includes specific quantitative results: 16 active components, 499 targets, 55 intersection targets from 3,194 disease genes.
• Employs a multi-method validation pipeline combining network pharmacology, molecular docking, and in vitro cell experiments.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download from the DOCX file.
• Row count is unknown, which may limit suitability assessment for computational analysis.
• The 3.7 MB file size suggests the dataset is small and likely contains primarily textual research documentation.

Provenance

Source

figshare

Collection Method

Data sourced from TCMSP, GEO, and GeneCards databases, with analysis via STRING, DAVID, and in vitro experiments.

Time Range

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Freshness

Last updated 2026-05-14 11:49:47; freshness should be verified.

Geography

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