Data Sheet 1_Extracellular caspase-1: a critical inducer and a therapeutic target of lung

A research article describing the discovery and role of extracellular caspase-1 (eCasp-1) as an alarmin in acute lung injury. The study includes data from critically ill surgical ICU patients and gut ischemia-reperfusion injury mice, published by Kouhei Ishikawa in 2026. The findings detail the GSDMD-dependent release mechanism and therapeutic targeting of eCasp-1-TLR4 interaction.

Use Cases

• Validate biomarker levels for acute lung injury based on eCasp-1 measurements in patient blood.
• Model inflammatory signaling pathways based on the described eCasp-1-TLR4 interaction.
• Assess therapeutic peptide efficacy based on the described C16 inhibitor's impact on survival and inflammation.
• Investigate gasdermin D (GSDMD) pore formation mechanisms in immune cell data mentioned in the study.

Strengths

• Data is associated with a peer-reviewed research article detailing a novel biological mechanism.
• Includes measurements from two model systems: critically ill surgical ICU patients and gut ischemia-reperfusion injury mice.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The primary data file is a 94.4 KB PDF, which likely contains textual results and figures rather than structured, machine-readable data.
• Column-level documentation and sample data are unavailable, requiring manual extraction and interpretation.
• Row count and dataset scale are unknown, limiting suitability assessment for large-scale analysis.

Provenance

Source

Kouhei Ishikawa via figshare

Collection Method

Experimental research involving patient samples, mouse models, and in vitro studies.

Time Range

Publication date suggests data generation likely occurred prior to 2026.

Freshness

Last updated 2026-04-15 05:45:43; freshness should be verified.

Geography

Geographic coverage of patient and animal studies is not specified.