Faecalibacterium Prausnitzii Effects on Sepsis-Induced Acute Lung Injury via Gut-Lung Axis

A research document describing a study on the probiotic Faecalibacterium prausnitzii and its role in sepsis-induced acute lung injury. The study used 16S rRNA sequencing and metabolomics on patient and murine model data to investigate the gut-lung axis. The document was authored by Xiaoli Feng and uploaded to figshare in May 2026 under a CC-BY-4.0 license.

Use Cases

• Study the correlation between gut microbiota dysbiosis and clinical inflammatory indices in sepsis patients based on the described 16S rRNA sequencing results.
• Investigate the mechanistic role of arachidonic acid metabolism and the LXA4-Nrf2-HO-1 pathway in lung injury based on the described non-targeted metabolomics analysis.
• Analyze the effects of probiotic intervention on gut microbial homeostasis and short-chain fatty acid production in murine models based on the described experimental methods.
• Explore interactions among gut microbiota, metabolomic profiles, and oxidative stress factors based on the described correlation analysis.

Strengths

• The study describes the use of two distinct murine models (cecal ligation puncture and lipopolysaccharide-induced) for validation.
• Analysis integrates multiple data types, including 16S rRNA sequencing, clinical indices, and non-targeted metabolomics.
• The document is shared under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• The primary data files (e.g., sequencing reads, metabolomics tables) are not directly included; the dataset is a 603.5 KB DOCX document summarizing findings.
• Row and column counts for the underlying experimental data are unknown, limiting assessment of data scale.
• Column-level documentation for any potential supplementary data is absent; field semantics must be inferred from the text.

Provenance

Source

figshare, author Xiaoli Feng.

Collection Method

The description indicates data was gathered via 16S rRNA high-throughput sequencing of patient samples and experiments on murine models, followed by non-targeted metabolomics analysis.

Freshness

Last updated 2026-05-28 14:54:38; freshness should be verified as this is a future date.