Fc-Mediated Antibody Functions and Disease Severity in 64 COVID-19 Patients

64 patients with laboratory-confirmed SARS-CoV-2 infection were prospectively studied to investigate relationships between Fc-mediated antibody effector functions and COVID 19 disease severity. The dataset, authored by Sungim Choi and last updated in May 2026, profiles antibody-dependent enhancement (ADE), cellular cytotoxicity (ADCC), and cellular phagocytosis (ADCP) activities against multiple SARS-CoV-2 variants.

Use Cases

• Modeling the association between antibody-dependent enhancement (ADE) activity and severe COVID-19 outcomes.
• Analyzing Fc gamma receptor-mediated reporter activities as surrogates for ADCC and ADCP across SARS-CoV-2 variants.
• Investigating the relationship between patient demographics, comorbidities, and dysregulated Fc-mediated immune responses.

Strengths

• Includes data from 64 patients with detailed severity classification (40 mild, 24 severe).
• Functional responses were measured against multiple SARS-CoV-2 variants, including wild-type and Omicron sublineages.
• Data is associated with a peer-reviewed research study with a clear methodological description.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is small in scale (784.8 KB), suggesting limited sample size for broad generalization.

Provenance

Source

figshare

Collection Method

Prospective investigation of patient Fc-mediated effector activities using pseudovirus and reporter cell assays.

Time Range

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Freshness

Last updated 2026-05-01 06:09:15; freshness should be verified.

Geography

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