FGFR2/STAT3 Signaling in MMTV-Related Spontaneous Breast Cancer in TA2 Mice

Molecular expression data from a study of spontaneous breast cancer in Tientsin Albino 2 (TA2) mice, related to mouse mammary tumor virus infection and pregnancy. The dataset includes measurements of FGF3, FGFR2, STAT3, and phosphorylated STAT3 in serum, normal mammary tissue, and cancer tissue across different pregnancy states, as well as results from cell line (MA-891) experiments and human breast cancer sample analysis. The 34.5 KB document was authored by Jiaxing Du and last updated on 2026-05-13.

Use Cases

• Analyzing the correlation between pregnancy count and MMTV-LTR amplification or protein expression levels based on measurements in TA2 mice.
• Modeling the effect of STAT3 inhibition on cancer cell proliferation and migration based on results from cryptotanshinone and Stattic treatments on MA-891 cells.
• Comparing STAT3 expression profiles between triple-negative and non-triple-negative human breast cancer based on the analysis of 139 clinical cases.

Strengths

• Includes data from a specific, high-incidence spontaneous breast cancer mouse model (TA2).
• Combines in vivo mouse tissue data, in vitro cell line experiments, and human clinical sample analysis (139 cases).
• Licensed under CC-BY-4.0 for open reuse.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small at 34.5 KB, indicating limited scope, likely containing summary results rather than raw experimental data.
• Data is contained in a DOC file format, which may require conversion for computational analysis.

Provenance

Source

figshare, author Jiaxing Du.

Collection Method

Experimental study involving molecular detection in mouse and human tissues, cell culture assays, and xenograft models.

Freshness

Last updated 2026-05-13 10:35:19; freshness should be verified.