Fibrinogen-like Protein 2 in Airway Smooth Muscle Cell Dysfunction

A research document details an in vitro study investigating the role of Fibrinogen-like protein 2 (FGL2) in platelet-derived growth factor-BB-induced pathological responses in human airway smooth muscle cells. The document, authored by Bo Zhao and licensed under CC-BY-4.0, was last updated on May 12, 2026. It systematically assesses cell proliferation, migration, extracellular matrix protein expression, inflammatory cytokine production, oxidative stress, and glycolytic metabolism.

Use Cases

• Analyze the role of FGL2 in cell proliferation and migration based on experimental results described in the document.
• Study the link between FGL2 and inflammatory cytokine production (TNF-α, IL-1β, IL-6) as outlined in the research.
• Investigate glycolytic reprogramming in airway cells based on described metrics like glucose consumption and lactate production.
• Validate computational models of PI3K/Akt pathway activation using the mechanistic insights provided.
• Identify potential therapeutic targets for airway diseases based on the described FGL2 knockdown effects.

Strengths

• The document provides a detailed methodological description of molecular and biochemical approaches used in the study.
• It presents specific, quantified results for multiple cellular processes, including cytokine levels and metabolic outputs.

Limitations

• The dataset is a single 218 KB DOC file, indicating a very limited scope and likely containing only textual results and descriptions.
• Row count and column-level data are unknown, requiring manual inspection after download to assess structured data availability.
• The description metadata is limited; actual data quality and format require manual inspection after download.

Provenance

Source

figshare

Collection Method

In vitro laboratory experiments on human airway smooth muscle cells, as described.

Freshness

Last updated 2026-05-12 05:43:02; freshness should be verified.