Fitness Costs of Cephalosporin Resistance Plasmids in E. coli from 40 Studies

An integrative review synthesizing molecular mechanisms and ecological dynamics of plasmid-mediated cephalosporin resistance in Escherichia coli. The dataset includes a PRISMA-guided quantitative synthesis of 40 studies, providing 154 experimental observations on fitness consequences. Author Lázaro López published the data on figshare in April 2026.

Use Cases

• Modeling plasmid fitness costs based on experimental observations from growth curve and competition assays
• Analyzing the influence of resistance gene families (ESBLs, AmpC, carbapenemases) on bacterial fitness
• Investigating the relationship between plasmid-host compatibility and dissemination potential across ecological niches
• Comparing methodological effects on fitness estimates, such as differences between head-to-head competition and growth curve assays

Strengths

• Includes a quantitative synthesis of 40 distinct studies on the topic
• Contains 154 curated experimental observations on fitness consequences
• Analysis accounts for hierarchical study structure using mixed-effects models
• Data is openly available under a CC-BY-4.0 license

Limitations

• Row count and column-level documentation are unknown; field semantics must be inferred after download
• The dataset is small (30.0 KB), indicating a limited scope focused on synthesized results rather than raw experimental data

Provenance

Source

figshare, author Lázaro López

Collection Method

Integrative review and PRISMA-guided quantitative synthesis of published studies

Time Range

Temporal coverage of the synthesized studies is not specified

Freshness

Last updated 2026-04-15 05:22:47

Geography

Geographic scope of the underlying studies is not specified