Data Sheet 1_Fluoroquinolones as the linchpin of tuberculosis therapy: contrasting efficac

A 2026 research paper by Magdalena Kuzioła details a phenotypic screening campaign comparing fluoroquinolone efficacy against Mycobacterium tuberculosis (Mtb) and Mycobacterium abscessus (Mab). The study, published on figshare under a CC-BY-4.0 license, identifies potent FQ derivatives effective against Mtb and explores intrinsic resistance mechanisms in Mab.

Use Cases

• Compare drug efficacy profiles based on phenotypic screening results described for Mtb and Mab.
• Study acquired resistance mechanisms based on point mutations in gyrA and gyrB genes mentioned in the description.
• Analyze cytotoxicity and bactericidal concentration (BC) data referenced from the screening campaign.
• Investigate molecular docking results for theoretical binding affinity to the gyrase complex.

Strengths

• The dataset includes detailed bactericidal concentration (BC) and cytotoxicity assessments.
• Analysis covers both Mycobacterium tuberculosis and Mycobacterium abscessus, providing a comparative view.
• The work explores both phenotypic screening results and molecular docking for theoretical binding affinity.

Limitations

• The dataset is a 1.5 MB PDF file; the underlying structured data (e.g., screening results, concentration values) is not directly accessible.
• Column-level documentation is absent; field semantics must be inferred from the paper text.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

Magdalena Kuzioła via figshare.

Collection Method

Comprehensive phenotypic screening campaign utilizing OTAVA and ECBD pilot-libraries, followed by detailed bactericidal concentration (BC) and cytotoxicity assessments.

Freshness

Last updated 2026-05-28 04:50:41.