Scoping Review on Organelle-Specific Autophagy in Skeletal Muscle

A scoping review following PRISMA-ScR guidelines, systematically mapping literature on organelle-specific autophagy in skeletal muscle. The review includes 113 studies, with 15% involving humans, 56% animal models, and 29% skeletal muscle cell lines. It was authored by Chunxiao Wang and last updated on 2026-05-07.

Use Cases

• Identify research gaps in non-mitophagy mechanisms based on the review's finding that mitophagy dominates the literature.
• Assess methodological quality in autophagy studies based on reported statistics for autophagic flux detection and risk of bias.
• Guide future clinical trial design based on the review's analysis of evidence levels, which found a predominance of low-level observational studies.
• Investigate sex and muscle fiber type specificity based on the conclusion noting the absence of systematic investigations in these areas.

Strengths

• Systematic methodology following PRISMA-ScR and Joanna Briggs Institute frameworks.
• Quantitative analysis of 113 included studies, breaking down contributions by study type (human, animal, cell) and autophagy subtype.
• Detailed assessment of methodological approaches, including that 53% of studies performed dual detection of LC3B and p62.

Limitations

• The dataset is a 101.5 KB PDF document; its scope is limited to the review's text and does not contain the primary data from the 113 studies.
• Row count and column-level documentation are absent; the document's structure must be inferred after download.
• The description is specific to the review's findings, but the actual data file content requires manual inspection.

Provenance

Source

figshare, authored by Chunxiao Wang.

Collection Method

Literature review searching PubMed, Embase, Web of Science, and Cochrane Library up to 21 March 2026.

Time Range

Literature search covered studies up to 21 March 2026.

Freshness

Last updated 2026-05-07 04:45:16; freshness should be verified.