Data Sheet 1_Functional and genetic divergence of aging-related TOMM40 polymorphisms in Al

A meta-analysis and bioinformatics study investigating the association of six TOMM40 polymorphisms with late-onset Alzheimer's disease risk. The work integrates evidence from 13 articles and incorporates genome-wide, regulatory, and functional genomic data from sources like IGAP/NIAGADS, AGORA, and GTEx. The dataset, authored by Shiqi Li and last updated in April 2026, is a 709.6 KB document summarizing the findings.

Use Cases

• Assessing genetic risk associations for Alzheimer's disease based on the meta-analysis results for rs2075650, rs157580, and rs157581.
• Investigating the functional genomic context of TOMM40 polymorphisms using integrated eQTL/sQTL and pathway enrichment evidence.
• Comparing the distinct mechanistic roles of risk versus protective variants in Alzheimer's disease as suggested by the integrative analysis.

Strengths

• Integrates multiple evidence types, including a meta-analysis of 13 articles and bioinformatics data from established genomic resources.
• Provides clear, statistically significant associations for specific polymorphisms (rs2075650, rs157580, rs157581) across genetic models.
• Distinguishes between risk and protective variants and suggests distinct biological mechanisms for each.

Limitations

• The dataset is a 709.6 KB document; the underlying raw data or column-level details are not provided.
• Row count and specific data structure are unknown, which may limit suitability assessment for computational reuse.
• Column-level documentation is absent; field semantics must be inferred from the textual description after download.

Provenance

Source

figshare, author Shiqi Li.

Collection Method

Comprehensive literature search across five databases, meta-analysis using RevMan 5.1, and integration of genome-wide and regulatory data from public repositories.

Time Range

Temporal coverage of the meta-analysis is not specified.

Freshness

Last updated 2026-04-10 05:58:17; freshness should be verified.

Geography

Spatial coverage is not specified.