Mouse Immune Cell Data on α-GalCer Protection Against Bacterial and Viral Infections

α-Galactosylceramide treatment in mice expands virtual memory CD8+ T cells, conferring protection against systemic, enteric, and pulmonary bacterial infections as well as pulmonary viral infection. The 1.3 MB PDF dataset, authored by Jia-Xun Xie and last updated in May 2026, details the immune cascade where activated iNKT cells produce IL-4 to expand CD8+ T_VM cells, which then provide TNF-α and IFN-γ-dependent protection.

Use Cases

• Modeling the protective role of virtual memory CD8+ T cells based on infection challenge data described.
• Analyzing cytokine production (IL-4, TNF-α, IFN-γ) dynamics in an α-GalCer treatment model.
• Studying the bystander protective potential of CD8+ T_VM cells against diverse pathogens as outlined in the mechanistic findings.
• Investigating lung-localized immune cell contributions to host defense as described in the results.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• The description provides a detailed mechanistic explanation of the observed immune protection.
• File size is precisely known (1.3 MB).

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The data is contained within a PDF, which may require extraction for computational analysis.
• The description metadata does not specify the organization or institution of the author.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from mouse model studies of infection and immune cell transfer, as described.

Freshness

Last updated 2026-05-22 06:10:12.