Data Sheet 1_Gastrointestinal dysfunction in patients with Mowat–Wilson syndrome is associ

A study of 35 patients with Mowat–Wilson syndrome (MWS) investigates intestinal symptoms, feeding difficulties, and fasting plasma neurotransmitter levels. The data includes questionnaire results on defecation and diet, and targeted plasma profiling via UPLC–TQ–MS, comparing patients with age-matched healthy controls. The dataset was authored by Lingya Liu and last updated on 2026-04-10.

Use Cases

• Correlating intestinal symptoms like constipation with feeding difficulties based on caregiver-reported questionnaires.
• Analyzing dietary composition differences, such as the proportion of meat, between patient and control groups.
• Investigating relationships between altered plasma neurotransmitter levels (e.g., serotonin, GABA) and clinical phenotypes.
• Modeling potential diet–neurotransmitter pathways relevant to gut dysmotility in Mowat–Wilson syndrome.

Strengths

• Includes data from 35 patients with Mowat–Wilson syndrome, a rare condition.
• Combines three complementary assessments: symptom questionnaires, dietary analysis, and plasma neurotransmitter profiling.
• Provides specific prevalence figures, such as 86% of patients having intestinal symptoms and 69% having constipation.
• Compares patient data with age-matched healthy controls (n=10).

Limitations

• Row count and column-level documentation are unknown; field semantics must be inferred after download.
• The plasma analysis subset is small (n=6 patients), which may limit statistical power.
• The dataset is small in scale (900.8 KB), indicating limited scope.

Provenance

Source

figshare, author Lingya Liu.

Collection Method

Data collected via patient/caregiver questionnaires and targeted fasting plasma neurotransmitter profiling using UPLC–TQ–MS.

Time Range

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Freshness

Last updated 2026-04-10 05:58:08; freshness should be verified.

Geography

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