Rat Gut Microbiota and Metabolite Responses to L-Se-methylselenocysteine

90-day chronic toxicity study on Sprague-Dawley rats explores dose-dependent and gender-specific effects of L-Se-methylselenocysteine. Integrated microbiome and metabolome analysis reveals impacts on intestinal homeostasis and hepatosplenic injury thresholds. Hui Zhang published this research on figshare in March 2026.

Use Cases

• Model dose-dependent toxicity thresholds based on administered selenium compound levels.
• Analyze gender-specific biological responses based on the described hepatosplenic injury outcomes.
• Study correlations between gut microbiota biodiversity and beneficial metabolite synthesis.
• Investigate the gut microbiota-metabolite axis as a mediator of supplement efficacy and safety.

Strengths

• Integrated analysis of microbiome and metabolome data from a 90-day chronic toxicity study.
• Explicit dose ranges tested (0.25–0.75 mg/kg bw/day and 2.25 mg/kg bw/day).
• Clear identification of gender-specific toxicological responses.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is specific to Sprague-Dawley rats; applicability to other species is unclear.

Provenance

Source

figshare

Collection Method

90-day chronic toxicity study on Sprague-Dawley rats combined with integrated intestinal microbiome and metabolome analysis.

Freshness

Last updated 2026-03-19 14:03:07