Gene Expression Profiles of Dendritic Cells in Systemic Lupus Erythematosus

Transcriptional profiles of in vitro generated dendritic cells derived from monocytes of individuals with systemic lupus erythematosus and healthy controls. The dataset is a 4.9 MB DOCX file authored by Ana Laura Hernández-Ledesma and last updated on June 2, 2026. It is licensed under CC-BY-4.0 and hosted on figshare.

Use Cases

• Identify disease-specific disruptions in tolerance-associated pathways based on transcriptional profiles.
• Analyze the role of interferon-stimulated genes as diagnostic and pathogenic markers in SLE.
• Investigate impaired IL-10 signaling and lipid metabolism pathways in tolerogenic dendritic cells from SLE donors.

Strengths

• Data is openly licensed under CC-BY-4.0.
• The description provides specific biological findings, such as the enrichment of key interferon-stimulated genes (IFI27, IFI44L, USP18, IFI6).
• The dataset was last updated on June 2, 2026.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The primary data file is a 4.9 MB DOCX, which may require extraction or conversion for computational analysis.

Provenance

Source

figshare

Collection Method

Transcriptional profiles were analyzed from in vitro generated dendritic cells derived from monocytes.

Freshness

Last updated 2026-06-02 09:03:44; freshness should be verified.