Genetic and Clinical Data on Insulin-Degrading Enzyme in Parkinson's Disease

A Chinese Han population study of 463 Parkinson's disease patients and 576 healthy controls, with an independent cohort of 100 patients and 100 controls for serum analysis. The dataset includes genotyping of 14 IDE gene SNPs and serum IDE level measurements, collected by author Huimin Zheng and last updated in May 2026. It investigates associations between genetic variants, serum enzyme levels, and clinical features of Parkinson's disease.

Use Cases

• Assessing genetic associations between IDE SNPs and Parkinson's disease risk based on the 14 genotyped polymorphisms.
• Investigating serum IDE concentration as a potential biomarker for Parkinson's disease based on the quantified levels in patients and controls.
• Analyzing correlations between serum IDE levels and clinical symptom severity based on the Mini-Mental State Examination scores and other assessed features.
• Conducting logistic regression to identify independent factors associated with Parkinson's disease based on the collected genetic and clinical variables.

Strengths

• Includes a primary cohort of 463 patients and 576 controls, plus a validation cohort of 100 patients and 100 controls.
• Genotyping covers 14 specific single nucleotide polymorphisms (SNPs) within the IDE gene.
• Clinical correlation analysis includes quantified serum IDE levels and Mini-Mental State Examination scores.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is specific to the Chinese Han population, which may limit generalizability to other ethnic groups.

Provenance

Source

figshare

Collection Method

Clinical and genetic investigation involving patient recruitment, blood sample collection, SNP genotyping, and serum IDE quantification.

Freshness

Last updated 2026-05-18 05:39:19; freshness should be verified.

Geography

Chinese Han population