Genome-Wide Association Study of Myopia Progression in Chinese Adolescents

294 Chinese adolescents completed a 2-year follow-up for a genome-wide association study (GWAS) of myopia progression. The study, authored by Qinye Liu and last updated in April 2026, identified seven novel suggestive loci and developed polygenic risk score (PRS) models for prediction. The East Asian training dataset showed an R² of 5.69% and an AUC of 0.66 for predicting myopia progression risk.

Use Cases

• Identifying genetic loci associated with myopia progression based on GWAS results from 294 adolescents.
• Developing polygenic risk score (PRS) models for predicting myopia progression risk in East Asian populations.
• Comparing the predictive performance of single-ancestry versus cross-ancestry PRS models for myopia.
• Conducting functional annotation and MAGMA analysis to explore the biological relevance of identified genetic loci.

Strengths

• Includes data from 294 Chinese adolescents with a 2-year follow-up period.
• Identified seven novel suggestive loci associated with myopia progression, including FSTL5 and SMARCA2.
• Provides specific model performance metrics, such as an R² of 5.69% and an AUC of 0.66 for the East Asian PRS model.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is specific to Chinese adolescents, which may limit generalizability to other populations.

Provenance

Source

figshare, authored by Qinye Liu.

Collection Method

Genotyping was performed using the Asian Screening Array chip, followed by a two-stage GWAS and PRS modeling with PRSice-2 and PRS-CSx.

Time Range

Study includes a 2-year follow-up period; specific start and end dates are not provided.

Freshness

Last updated 2026-04-21 11:20:42; freshness should be verified.

Geography

Data is from Chinese adolescents.