Primary Sjögren's Syndrome Gene Expression Data from 126 Minor Salivary Gland Samples

126 minor salivary gland samples from patients with primary Sjögren's syndrome and controls were analyzed via deep stranded total transcriptome sequencing. Zhongshan Li published this dataset under a CC-BY-4.0 license in April 2026. The data supports the construction of a genome-wide competing endogenous RNA network comprising 3,035 lncRNAs and 10,838 coding genes.

Use Cases

• Identify differentially expressed genes between pSS and control groups based on transcriptome sequencing data.
• Construct competing endogenous RNA networks based on shared miRNA binding sites and gene expression correlations.
• Validate regulatory roles of specific lncRNAs like BISPR, LINC00926, and HCP5 through in silico analysis.
• Investigate the contribution of lncRNAs to dysregulated biological pathways in autoimmune disease.

Strengths

• Includes 126 samples (92 pSS patients and 34 controls), providing a basis for comparative analysis.
• Data underpins a constructed genome-wide ceRNA network with 3,035 lncRNAs and 10,838 coding genes.
• Regulatory roles of three key lncRNAs were validated by in vitro experiments, suggesting functional relevance.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is presented in a PDF format (956.4 KB), which likely contains summarized results rather than raw data tables.

Provenance

Source

figshare, author Zhongshan Li.

Collection Method

Deep stranded total transcriptome sequencing performed on minor salivary gland biopsies.

Time Range

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Freshness

Last updated 2026-04-15 05:33:15; freshness should be verified.

Geography

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