Genomic Determinants of Antifungal Activity in Streptomyces Strain STM-2

Featuring genomic analysis results for Streptomyces melanosporofaciens STM-2, a strain isolated from Chiayi County, Taiwan. The study identified 52 biosynthetic gene clusters (BGCs) and genes for antifungal enzymes like chitinases and proteases. It was authored by Muhammed Opoku Gyamfi and published on figshare.

Use Cases

• Analyze the 52 predicted biosynthetic gene clusters (BGCs) to identify potential novel antimicrobial compounds.
• Study the accessory genome and unique genes linked to specialized antifungal activity through comparative genomics.
• Examine the predicted genes for antifungal hydrolytic enzymes like chitinases, β-1,3-glucanases, and proteases for biocontrol applications.
• Use the high-GC (71%) linear chromosome data for evolutionary analysis of Streptomyces strains.
• Investigate the in silico structural models of unique gene products generated with AlphaFold2 for functional protein studies.

Strengths

• Identifies 52 biosynthetic gene clusters (BGCs) including type I/II PKS, NRPS, and hybrid systems.
• Provides genomic data for a novel Streptomyces melanosporofaciens strain with a high-GC (71%) linear chromosome.
• Includes comparative pangenomic analysis supported by ANI and dDDH scores to establish evolutionary uniqueness.
• Contains in silico structural protein models generated using AlphaFold2 with high pLDDT scores.

Limitations

• The dataset is very small at 1.4 KB, indicating limited scope, likely a summary or metadata file rather than raw genomic sequences.
• Specific data structure (rows, columns) and sample data are unavailable, hindering direct analytical use.
• Findings are based on a single strain (STM-2) from one geographic location (Taiwan), limiting generalizability.

Provenance

Source

figshare, authored by Muhammed Opoku Gyamfi.

Collection Method

Integrated approach involving genome sequencing, annotation, mining with antiSMASH, comparative genomics, and in silico structural modeling with AlphaFold2.

Freshness

Last updated March 20, 2026.

Geography

Chiayi County, Taiwan.