Genomic Distribution of Linezolid Resistance Genes in Enterococcus Faecium

243 genomes from a collection of 2,235 publicly available Enterococcus faecium genomes carry at least one linezolid resistance gene. The dataset, created by Xiaoxiao Yuan and last updated in April 2026, provides genomic insights into the distribution of optrA, poxtA, and cfr genes across sequence types and virulence backgrounds.

Use Cases

• Analyze the co-occurrence of optrA and poxtA resistance genes within individual isolates.
• Correlate specific sequence types (STs) with the presence of linezolid resistance determinants.
• Identify enrichment patterns of adherence-associated virulence genes in isolates with multiple resistance genes.
• Examine the phylogenetic distribution of resistance genes to assess horizontal gene transfer evidence.
• Compare the prevalence rates of poxtA (8.1%), optrA (6.9%), and cfr (2.2%) across the genomic collection.

Strengths

• Analysis based on 2,235 E. faecium genomes provides a substantial sample size.
• Identifies 243 positive genomes (10.9%) and characterizes distribution across 90 distinct sequence types.

Limitations

• The 479.2 KB file size suggests the dataset is a summary or analysis sheet, not the raw genomic sequences.
• Specific sample-level data columns and the original row count for analysis are not provided.

Provenance

Source

figshare, author Xiaoxiao Yuan.

Collection Method

Large-scale genomic analysis of publicly available E. faecium genomes.

Time Range

null

Freshness

Last updated in April 2026.

Geography

Global dissemination focus, but specific geographic coverage is not detailed.