Genomic Surveillance of Carbapenem-Resistant Klebsiella Pneumoniae in Moldova, 2020-2023

Svetlana Colac's dataset comprises genomic and phenotypic data for 99 Klebsiella pneumoniae strains collected from nine Moldovan hospitals between 2020 and 2023. Phenotypic testing showed high resistance to key antibiotics, including 68% resistance to carbapenems. Whole-genome sequencing identified 16 distinct MLST types, with ST395 being the most prevalent, and characterized associated resistance genes, plasmid types, and virulence scores.

Use Cases

• Phylogenetic analysis of strain dissemination based on identified MLST types and hospital sources.
• Correlation of phenotypic antibiotic resistance profiles with genotypic resistance markers like blaOXA-48 and blaNDM-1.
• Investigation of plasmid-mediated resistance spread based on reported Col and Inc plasmid/replicon types.
• Assessment of virulence potential and risk profiling using the reported virulence scores for hypervirulent lineages like ST23.

Strengths

• Includes 99 bacterial strains with linked phenotypic and genomic data.
• Provides specific resistance percentages for four major antibiotic classes (e.g., 98% to third-generation cephalosporins).
• Identifies 16 distinct MLST types and details the most common lineages (ST395, ST377, ST23).
• Reports concrete findings on resistance gene carriage and plasmid types for the dominant ST395 cluster.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is contained in a DOCX file, which may require extraction and structuring for computational analysis.

Provenance

Source

Svetlana Colac via figshare.

Collection Method

Strains were collected from nine hospital laboratories and analyzed using conventional phenotypic methods and whole-genome sequencing.

Time Range

January 2020 to December 2023

Freshness

Last updated 2026-03-18 06:42:20; freshness should be verified.

Geography

Republic of Moldova